Potato protection against blight is an indispensable element of cultivation technology in all production systems. Having in mind food safety and environmental protection, the goal is to limit the chemical protection of plants in favour of other methods, including biological ones. Therefore, the study aimed to evaluate an effect of chemical (Ridomil Gold MZ 68 WP and Infinito 687.5 SC, Flowbrix 380 SC), biological (Polyversum WP, Timorex Gold 24 EC, Biosept Active 33 SL) and integrated protection (alternate biopreparations and Flowbrix 380 SC) on tuber yield of early (Vineta) and moderately early (Red Fantasy) potato cultivars. The field experiment was carried out in the years 2012-2014 near Cracow, Poland (50º07’N, 20º05’E and altitude 271 m a.s.l.) in soil conditions of Luvic Chernozem, developed from loess. Potato protection against blight contributed to a significant increase in yield in all variants of protection, except Polyversum WP. Ridomil Gold MZ 68 WP and Infinito 687.5 SC fungicides were the most effective; their application resulted in 35% higher tuber yields compared to the control plants. Flowbrix 380 SC application caused a 22% yield increase, while plant extracts used individually and alternately with Flowbrix 380 SC fungicide resulted in 16-17% increase.